Shire plc plans to relocate more than 500 positions from its Chesterbrook, PA site to Lexington, MA, which will now serve as the company’s U.S. operational headquarters. The shift will occur in several phases beginning in 1Q15 with a targeted completion in 1Q16.     The transition is part of the company’s ‘One Shire’ efficiency program aimed at streamlining business globally through two principal locations, MA and Switzerland, with support from a limited number of regiona...